Corrigendum: Biased Signaling of Protease-Activated Receptors

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Corrigendum: Biased Signaling of Protease-Activated Receptors

1 Monash Institute of Pharmaceutical Sciences, Parkville, VIC, Australia 2 Department of Pharmacology, University of Melbourne, Melbourne, VIC, Australia *Correspondence: [email protected] Edited by: Michael Weiss, Case Western Reserve University, USA Reviewed by: Charles Roberts, Oregon National Primate Research Center, USA Michael Lawrence, The Walter and Eliza Hall Institute of Medica...

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Biased Signaling of Protease-Activated Receptors

In addition to their role in protein degradation and digestion, proteases can also function as hormone-like signaling molecules that regulate vital patho-physiological processes, including inflammation, hemostasis, pain, and repair mechanisms. Certain proteases can signal to cells by cleaving protease-activated receptors (PARs), a family of four G protein-coupled receptors. PARs are expressed b...

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Differential Signaling by Protease-Activated Receptors: Implications for Therapeutic Targeting

Protease-activated receptors (PARs) are a family of four G protein-coupled receptors that exhibit increasingly appreciated differences in signaling and regulation both within and between the receptor class. By nature of their proteolytic self-activation mechanism, PARs have unique processes of receptor activation, "ligand" binding, and desensitization/resensitization. These distinctive aspects ...

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Protease-activated receptors in inflammation, neuronal signaling and pain.

The ability of proteases to regulate cell function via protease-activated receptors (PARs) has led to new insights about the potential physiological functions of these enzymes. Several studies suggest that PARs play roles in both inflammation and tissue repair, depending on the cellular environment in which they act. The recent detection of PARs on peripheral and central neurons suggests that n...

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ژورنال

عنوان ژورنال: Frontiers in Endocrinology

سال: 2015

ISSN: 1664-2392

DOI: 10.3389/fendo.2014.00228